I fly about ~150K w/ LH/LX per year and ~80K miles with CX/JL/AA per year. Most of my flights are international to Europe (ZRH/LHR) and Asia (HKG/NRT). When I fly in the US, I mostly fly Jetblue and Virgin (F)
Luckily we have very liberal travel rules, all international flights are booked in C or F (if no availability in C), free choice of airline.