Met a chap in Singapore last Wednesday evening who regularly does 400K+ per year these days, much of it commuting SIN-SYD. I asked him to look me up if he's ever in Boston. "How about in two weeks?" was the reply. I hope it happens - he has some great stories!
(He owns his own company and buys economy tickets. He's often upgraded, of course, and understands the FF "game" well, but he does a good fraction of those miles in the small seats. Fortunately for him, he's not large for a guy.)