USAirways is probably your most direct route, with the exception of Delta flying through Covington. Atleast connecting in Pittsburgh gives you a huge airport with a lot to do during a layover.
As for FF programs, I've never flown DL, so I would check out their board to see what changes they've made recently. US has been up and down over the last year. They have a lot of bonus mile opportunities, but they've been growing more and more towards targetted offerings. The codeshare with UA greatly expanded their international and western US destinations.
HTH,
T.C.
(Edit: Most imnportantly, WELCOME TO FT!)
[This message has been edited by tcollins33 (edited 02-20-2003).]