My wife had acute appendicitis a couple of years ago, during the e.coli spinach scare in California, and was told that although there was no way to be certain, e.coli poisoning can sometimes lead to appendicitis. While she was recovering and I was in CA visiting her, I developed the worst case of food poisoning I've ever had (debilitated for about five days), after eating a spinach salad--again, there was no way to know for sure, and I coudn't develop appendicitis because I'd already had an appendectomy.