I've gotta say, I'm a self-proclaimed expert at packing. I can get a week's worth of business attire plus ancillary items (electronic chargers, some workout gear, etc.) into a 22" rollaboard. And no wrinkles. I follow the roll-up your stuff method religiously and it works great - I've never had to touch a hotel iron or send stuff out to be pressed. Today's wrinkle-free or no-iron fabrics are terrific for the road warrior.

Thus, my vote is - roll up yer stuff!