we had a DO at the Lyon Hilton and its wonderful. a little bit outside city center (15min by bus/tram/metro) but next to a wonderful park ...

I can recommend it. nice, new hotel.
The Radisson is the former LeMeridien, its the highest building in the city and hotel starts at 30th floor IIRC. older and smaller rooms, but a nice bar worth the visit in the evening to enjoy view all over Lyon.