Absolutely - preferably upstairs.
OP didn't mention if it was a 747 or not, but obviously, this goes without saying
If not - what is the preferred block of 4 in the centre?
They're all much of a muchness apart from the last row in any cabin, because the centre pairs in that row have unrestricted access. They also have the bassinet positions, though, so aren't available until T-24 (or T-72 - YMMV).