I agree that Noon Thurs. - 11:59p Monday is the general definition, but I also have found that it does vary in a couple of ways.
First, some locations (IME usu. Florida) allow a pick up before Noon Sun. and drop off Tues. and will give a weekend rate (altho that may be higher than a normal weekday rate depending on car class).
Second, hertz has at least three different weekend rates depending on the days you rent and they can be counterintuitive. For example, I have seen the following at an HLE (airports could differ): Rent F-Su, lowest weekend rate; rent Sa-M, lowest weekend rate: rent F-M, middle weekend rate. Said differently, if you rent for three days, you pay a higher daily rate than if you rent only two days.
If your dates are flexible it can be worthwhile to check all the alternatives. A tad tedious, but not without some meaningful results at times.