I use them all the time for Airport Hotels, after all unless you want the Hotel that is connected to The Terminal and usually charges double everybody else, Priceline is great.
After all 3 star Airport hotels are very similar. My latest recent example got the Hilton LAX for $60 and thanks to my status was upgraded to Club Room and Lounge. Next week I am staying at the Hyatt Regency ORD for $65..rack rate $189^