I would love to see B6 begin service into MSP. I vote MSP-BOS.
If B6 begain MSP-JFK I think that market competition is too strong and B6 would get shut out within a few months.
I know that the AA service from MSP-LGA is struggling due to competition with NW, SY, and CO. I think B6 would have difficulty capturing the business traveler which you commonly see on this route as they don't have a very developed elite program. I would personally sacrafice a few more dollars to fly on DL or NW in hopes of getting an upgrade and FF miles that I can use to travel almost anywhere in the world.
On the other hand the only competition with MSP-BOS would be NW. I know these flights are almost always full but I know a lot of these passengers are also passengers making connections in MSP which wouldn't might not work with the plan.