Ambien has a warning to not take it with alcohol. I am told that the reason for the warning is that alcohol increases the effect. Usually, that is exactly what I want, so I usually have a glass of wine with my overseas flight and take the Ambien right after the meal. Typically, I wake up about the time that they are handing out the customs cards. Perfect. Once on a hellish Air France flight where I was seated in non-reclining seats next to the toilet, I took 15mg of Ambien (1+1/2 pills) plus wine. I don't even remember the flight yet I woke up alert and refreshed just as they are handing out the customs cards.