It depends on what you are looking to do during the week. There are a lot of hotels in Cocoa Beach with good access to the beach. There's also easy access to the Beach-Line (528) which gives you a easy route into Orlando to all the theme parks (Sea World, Disney, Universal Studios). The Space Center is also not far from there.

A little futher down the coast there are beachfront hotels in the Melbourne/Indialantic area. Those beaches are typically a little less crowded than Cocoa Beach.