I'll often stick my main ntoebook in my suitcase under my clothes. Or in a pocket on it. I keep backups of my data separately, and the more sensitive data is encrypted with the TPM module found on most modern business notebooks.
I know it's not fool proof, but I guess I'm relying on out of site, out of mind.
I guess I'm a hotel risk taker. I don't wrap the remote control in a zip loc bag either.
Cromely.