"Actually if I am traveling in F normally bottle or two of Krug/DP, few samples of good quality reds, and fews glasses of JW Blue will knock me out. No chemical substances needed. "

Alcohol is a chemical substance. The problem is, it is one that dehydrates you and can lead to a bad case of jet lag. That is not to mention the health issues brought on by chronic drinking while traveling for work. Staying hydrated on an intercontinental flight is difficult enough without adding alcohol into the mix.

Some people, seemingly yourself included, can sleep quiet easily and while you can manage to get away with drinking a few bottles of wine on a flight, I would suggest that having 10-15 drinks during the course of your trip isn't the best way to start or end a business venture. The drinking, eating, lack of activity and jet lag all catch up with your ticker at some point.