I would be at the airport no later than 1 hour before the flight. It shouldn't be too busy on a Saturday morning. Checking bags should be a snap and TSA shouldn't be too crowded. So, I would leave from the hotel 1.5 hours from departure time. That should leave ample buffer time.

If you want to be extra cautious, maybe tack on an extra 15 minutes to account for some random unexpected delay, like a secondary screening at TSA or something.