It can't hurt, I usually put my link titles in bold, but the URLs I normally leave in the regular formatting. I find that the blue tends to get lost at a quick glance (especially short link titles). I might have seen it in bold, but I read the first paragraph and decided to reply at that point, and didn't read further while writing my reply (which I usually do).

BTW, I recommended combining this into the other thread.

EDIT: I'm going to have to leave a Firefox tab open to the TalkMail page, because I keep forgetting to read it without the reminder of the e-mail. BTW, you can see by the drop-down how frequently they're sent out.