Yes, you're in full-blown "disease" mode if you hotel-hop. It's even worse if you have to turn in hotel receipts for a business trip.
Fortunately, my experience with hotel-hopping took me down a category from our usual business hotels. (Usually folks book standard 3-star Hiltons and Marriotts; my hotel-hopping to hit Conquest bonuses took me to every Hampton Inn, HGI, and Embassy in the Tampa area.

) So no one ever asked any questions...