We took the Eurostar from Venice to Rome (it stopped in Florence). As we were going on a transatlantic cruise from Rome we had alot of luggage. We took a private water taxi to the station (expensive but worth it) and there was a fellow with a little tractor and cart waiting (we didn't arrange in advance but I'm sure he figured if we were using private transportation we would use him - boy was HE right). He took us to the terminal and waited until our train came in and loaded our luggage. We had bicycle cable locks and threaded them through the luggage as we were warned that sometimes people will jump on at a stop and grab the luggage as it is at the end of the car. When we got to Rome we looked around and again used someone although they had alot of carts available. It is just getting the stuff off and on the train that can be difficult. The food on the train was heavy (pasta and then a meat dish) so you might want to take some paninis with you.