Well you know that 380 is pretty quiet, and I imagine even more so in R class (I was in C so can only guess ) so yeah... if you/your partner is loud.. could get interesting... though isn't that what NR headsets are for.

In C all we got was this guy whoose snoring kept me awake!! LOL. He was way louder than the engines noise.

by the way the upper forward lav might be a good mile high location too... ahem...