Looking over the Idine list, I don't see any places that are destinations -- just places that are good if you happen to be in the neighborhood.

With that in mind, your best bets are 21st Amendment (down by the ballpark), Citizen Cake (Hayes Valley, near the opera house), and Eastside West (in Cow Hollow). Of those, Eastside West is the only one where you can spend a significant amount of money.

I've heard positive things about Ramblas, the tapas bar in the Mission, but I've never eaten there.