I had 22A on a simple SFO to ORD one time and vowed NEVER to take that seat or any near it ever again.

Pax chatting while stretching legs, lots of galley activity, people coming down the stairs all made it a miserable experience.

This was over a year ago, and they didn't have the newer C seats so I had to watch a tiny TV monitor buried in the ceiling. It was dreadful.