Flyertalk Evangelist and Moderator: Coupon Connection and Travel Products
Join Date: Jul 2000
Location: Milton, GA USA
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Posts: 19,040
Your biggest issue will be if you have any irregular operations. Since they would be separate tickets, the airline is only responsible for getting you to the final destination on that ticket. Not your ultimate destination. Unless you are leaving a great deal of time to connect, it is a risky strategy.
The other issue... as graraps said... is the luggage issue.