I noticed that the X10 and X12 rooms were handicap rooms on my last two stays. Not sure if this is true in general.
I recently stayed in 210 at HP Medford, MA. It was not a handicap room.
Haven't stayed at enough HP's to give much other input on room layout. This one had an "L'" shaped sofa. The location of the bathroom sink was annoying (right in the bedroom). I'd think twice about staying again--only if all room occupants plan to wake up at the same time.