At the risk of starting a forum brouhaha, the term "bridge and tunnel" is a nasty expression originally meant to insult anyone who resides outside of Manhattan. Of course, this would logically place more "value" on a drug dealer living in upper Manhattan's Washington Heights section than an investment banker living in Brooklyn Heights.
These days, when people say "bridge and tunnel" what they are usually suggesting is a group of low class, poorly dressed individuals.
I personally loathe this term.
Back to your question, however. On West 27th, 28th and 29th Streets between 10th and 11th Avenues, there are many clubs of the kind you mention such as Crobar, Guesthouse, Home, Pink Elephant, Stereo and Bungalow 8. The last one has a notoriously difficult door policy. Also nearby is Marquee on 10th Avenue between 26th and 27th Streets, allegedly frequented by Paris Hilton when she is in New York, if you believe the gossip columns.
I am not a regular in any of these places but if I were betting, I'd give you better odds this coming weekend than any other because, as previously pointed out, the "A-list" crowd is in the Hamptons.
Also, sorry to say, many of these establishments have a horrible policy called "bottle service" in which in order to secure a table you have to order alcohol by the bottle at very high prices, e.g. $200 for a bottle of vodka. This is not obligatory and you can always buy drinks at the bar.
If you are staying in a hotel, someone there may be able to give you more current information.
I hope you enjoy your stay in New York. I'll be away for the weekend.
