The road is dual carriage way for just about the entire route.

Travelling is easy with no more than 9½ to 10 hours of actual driving.

If you are looking at stopping around ½ way, then Tarcutta and Gundagai would be your best bets.

Albury is fine to stop as well, from there it's about 3½ hours to Melbourne CBD.

I would avoid arriving after 3:30pm weekdays and 5pm on Sundays due to traffic congestion.