A few things to consider...

One is that it could be something very innocuous, but my gut says it is an SSSS.

To reduce the burden of physical touching, I would recommend wearing shorts and a short-sleeve shirt. Some TSAers will wand and pat down bare skin, but I think most won't.

If you want to lessen the baggage burden, you can take her carry-on through yourself if you do not have SSSS. But be careful, if it's obvious to the TSA as to what you're doing, both of you will get the business.

If you do that, I would recommend staggering yourself in line position...put a couple of people in between you and her, or go in separate lines altogether. You may also consider putting her purse, or at least most of the items, in your carry-on to reduce further pawing.

Also remember that any checked bag she has under her name will be opened and searched. There are plenty of TSAers (and contractors) who have sticky-finger syndrome. You might want to consider checking all the bags in your name. Remember, if you're 1K, you can check three bags, all up to 70 pounds each.

Last but not least, TSAers are required to do three things upon a passenger's request during a search. 1) Put on a fresh pair of gloves. 2) Do a private screening, out of the eye of the general public. 3) Have a supervisor present (but I don't think you'll need that).