As long as you do a 360 at least once a year as others have said getting to the oiunt of origin is only a problem once.
My next AONE end/pickup I am taking a safari in Botswana (on horseback!), last time I did CPT, MRU itself is great for a day in the sun/windsurfing.
For me the best thing about taking ONE's away from where you live is to get the extra segments where you are based in the middle of the ticket.
I've also got used to A class and the next cheapest place doesn't come close does it? - where is it these days?
Also really important for e is baggage allowance and when in F (with the exception of AA) I have never been charged with stupid amounts of luggage including skis etc that saves both hassle and money.