Mark Hopkins Suite at the Mark Hopkins InterContinental in San Francisco. It was part of the deal when me wife and I got married there. Simply awesome views from the balcony. And the bathroom, dining room and bedroom were great and will. The after party in that room was the greatest, even if I say so myself.
My wife and I have stayed at many 5 star hotel since, but we know that no other room will ever come close. I think its rate is $5,000 per night. But I could be wrong.