As Fornebufox indicates, the wineries are located in the Santa Ynez Valley and surroundings, a very pretty 45 minute drive (either via 154 or 101) from Santa Barbara. I grew up in SB, and my family lives in the Santa Ynez Valley, so I'm familiar with the wineries as I visit every other month. The area is like Napa was 30 years ago (before the tour buses arrived there). Most of the dozens of wineries make good wines, and driving along the two lane back roads is part of the enjoyment of this area (it's also signficant horse country). That said, I would not head up to the SYV just to go to one winery, unless you want to make a nice road trip over the 154 and back down the coast on the 101.

There are many wineries that will give you a combination of good wines and a pretty setting, some better than others in each category. I'd have to respectfully disagree with the Sanford recommendation. While it's is a pretty setting (though a bit out of the way from other wineries), the Sanford family and winemakers are no longer there as a result of an unpleasant dispute, and how good the wines will be under a new winemaker is yet to be determined (was not that impressed with a recent tasting), and if you're only going to one winery, you want to make sure you're going to get good wines.