I book most of my stays at Marriott and Hilton family brands. The main reason is consistency. My business travel usually means arriving late in the evening and having to be up early the next morning for a full day with clients. I want to be confident that my room will meet my standards for comfort, appearance, and functionality (e.g., in-room Internet). I've tried other chains within similar price ranges, and they don't do well enough on a consistent basis. For example, Holiday Inns have just never appealed to me, and my experience with Sheratons has been hit-or-miss.

Secondary reasons are prevalence and loyalty programs. Radisson meets my consistency standard, but they have few properties and their rewards program is stingy. Still, I stay with them if there's a property where I'm going and it undercuts the MR/HH brands on price.