I try to upgrade anything over 4 hours which pretty much covers all transcons and transoceanic flights. Arriving well rested is important, especially when traveling for business.
Outbound flights to Europe usually arrive early in the a.m., which means your hotel room will probably not be ready. On transatlantic flights, business class will, depending on the carrier, grant you access to arrivals facilities which have showers and a light continental breakfast. A great way to start your day, even if it's a leisure trip.
Gambling on a flight being empty in coach, or full which may mean an operational upgrade, just doesn't cut it for me.