I am new to this but looking at the seat maps, wouldn't the best seats in coach be 10 A&B,H&J OR 22 A&B,H&J? I understand either window seat in row 22 is a minor inconvenience if you have long legs. The exit doors protrude slightly, but if you angle your legs you have plenty of room.

If you are on a long return flight, lets say Honolulu to Minneapolis, I would avoid 10 A&B and 10 H&J, as they are near the bathrooms.

This is under the assumption that you are trying to find two seats together.