Originally Posted by
outbound10
I would recommend the Grand Hyatt on Union Square or the Hyatt at Fisherman's Wharf. Grand Hyatt for it's amazing views and close proximitiy to shopping and Fisherman's Wharf for it's recently renovated rooms (32" LCD TV's in all rooms) and fitness center as well as being close to all tours such as Alcatraz etc. Fisherman's Wharf has limited views compared to the other two, but has the best rooms.
I'd go for the Grand Hyatt: it has a great location and there's lots to do there, day and night. I haven't stayed at the Fisherman's Wharf, but I can't imagine it can beat the activity in the evenings in and around Union Square.