So far the only thing that doesn't work is my Dymo label printer.
I am disappointed that a company as large as dymo still doesn't have drivers ready for an OS that has been available to them as beta for almost a year. Logitech released the drivers for my keyboard today, not a moment too soon either.
Ran into some problems with Acrobat, but it just turns out that it won't install if the stupid user account protection is disabled...