I have done this many times.

If I am simply using a room primarily as a place to sleep for a few hours and have a place to clean myself, almost any accommodation will do as long as it is reasonably clean. This is where I attempt to keep my lodging costs as low as possible.

If I am going to spend significant time in a room, that is when I want to take advantage of comfort, amenities and extras. Then, I will stay in a better hotel property.