I have a similar problem that occurs a few times a day. Doesn't seem to be linked to mouse location, though. A Microsoft Internet Explorer window pops up with the text "Internet Explorer cannot open in the internet site http://www.flyertalk.com/forum/showthread.php?t=636498. Operation Aborted." I have a screenshot that can be provided if requested.

I click the "OK" button, and get Page Cannot be Displayed, but get the page when I clikc the "BACK" button. (Firefox is not an option for me at work.)