I think I grasp your point - that, even though the geographical distances might not be vast, the *perception* of the listed locations is quite different.

I am in full agreement with you that the Gendamenmarkt (not Potsdammer Platz or Ku'dam) is the true center of the united city - on my last trip, in fact, I had originally booked one night at the Westin and one night at the de Rome (I went to CPH in between) - I changed the Westin night over to the Melia when I discovered that it had opened, so that I could try it out.

One conclusion that anyone who looks at the Melia building will draw is that it would have been prohibitively expensive to have built a hotel of that size close to the Gendamenmarkt itself. I of course concur that, for a person with mobility challenges, the Melia is not the best choice. But for someone without mobility constraints (and who will ride the BVG extensively), the Melia, and also the Mercure location mentioned by WillTravel, should at least be kept in mind (especially when rates in the better-situated properties climb).

BTW, good spotting of the Hyatt - (it's at 42nd and Lexington, one very short block from 3rd)