Perfectly right, but still not "the place to be". For a Berliner, this is somehow "out of town". Back to comparing Berlin to NYC: If you consider Rockefeller Center to be the "Center of Manhattan", the Hilton (Regent, Dorint, de Rome) would be there, the Westin is where W=A is located and the Melia - well, I believe there is a Hyatt at 42nd street / 3rd Ave....

The Melia is simply in the wrong direction if you understand Gendamenmarkt as the Center of Berlin-Mitte. Oranienburger Straße is nice but maybe not the location to go to for somebody with certain difficulties to walk