Tops: Houston. I had expectations entering without much preconceived notions and did not like anything about it. 90F at 9am, 90% humidity. Couldn't breathe, traffic was horrible at 11am on a tuesday... no wonder why the I-10 is going to 30 lanes. Traffic doesn't move otherwise..
Reno. Well, it's really not TOO bad. it's below the snow line (in most cases) which makes it fairly decent. Windy a lot, and downtown is tacky.
Atlanta: I had high hopes.. all the rappers talk about it. I even stayed in Buckhead... zzzz boring.. bad traffic and seemed really run down, even on Peachtree blvd...
Baltimore. I live 80 miles away and barely know my way through the city on 95. Never been to the harbor, despite the fact i know a guy who works for the Orioles and could get me box tix for any game.
I have to defend LA. I really, really like it. In fact, I find it to be more of a city than San Diego, Sacramento, Las Vegas, Phoenix and San Jose.. probably combined. The city has a LOT to offer. traffic does suck, the air's pretty bad and the people aren't the best this planet offers, but it's really, really got a lot of great restaurants and great neighborhoods.
For the record, I've never lived in LA.. been ~50 times... friends/family live(d) there... living there could suck.. i really don't know tho.
Orange County's a nice place to live, but a cultural wasteland like San Diego is.. San Diego is a gigant suburban sprawling city.