They are not open on weekends, but I did receive an email (auto generated itenerary) on Saturday morning 4 AM EST. I guess they just submit the request and the computer does the rest based upon its queue.

Also, I did change the route at least 4 - 5 times over the last couple of weeks for a variety of reasons and they have been very cooperative each time. I am going to call them Sunday night from here (NYC) for final ticketing.