I've consulted with many non-profits and each one is different... I wouldn't say I have a standard toolset to recommend across the board...

However, I would like to recommend a website called TechSoup.

At http://techsoup.org/ they bill themselves as "the technology place for nonprofits". There you will find forums and articles with how-to's and how-we-did's for many of the issues you raise now and will likely run into in the near future. Also, they offer access to discounted software and services specifically for non-profits, including microsoft licensing, adobe licensing, symantec/antivirus, cisco, etc....

See their articles:

Ask TechSoup: Open-Source Tools for Fundraising?
Free, customizable donor databases and CRM applications
http://www.techsoup.org/learningcent...g/page5934.cfm

A Few Good Email Newsletter Tools
Reliable, affordable ways to send out email in bulk
http://www.techsoup.org/learningcent...t/page5935.cfm

I think you will find some good information here, and be able to make decisions that closely match your organization's needs and structure.

Also, gleff mentioned salesforce.com license donation... get the details here:
http://www.salesforcefoundation.org/product/