Been there, done that. Who needs jet lag when you have adreneline (enthusiasm) and coffee?
A few years back I spotted one of the next weekend cheap fares in an AA email, and I had an AA voucher that was about to expire. Mrs. Gargoyle and I went to paris for a 3 day weekend, spent $1000 total for air fare, hotel, food and shopping. We had a great time..
Each winter we do a 3 or 4 day MR to somewhere in Europe, those are fun.
I've done many 2 and 3 day trips to Italy. One last year (a B/E award ticket in July booked about 5 days prior to the trip, who says you can't get DL award tix if you try); routing was a bit rough due to the last minute nature, spent 48 hours travelling, and had 52 hours in Italy, finished all my work in the first 36 hours and then relaxed and hung out with friends.