If your hotel doesn't have a concierge, or you want to buy your own tickets to the Uffizi or Accademia, you can buy them from the US on line
http://selectitaly.com/museums.php?ref=yahoo. I would also suggest (depending upon how long you'll be there) a couple of quick side daytrips that can be easily done via bus to : Sienna, Chianti region, Pisa, Lecca, Fisole etc. The buses are frequent & cheap (as an example: to Greve in Chianti it's e2.90 each way--takes about an hour and you ride through the beautiful Tuscan countryside ^
http://www.greve-in-chianti.com/ ).