Well, certainly if they sorted the passengers according to their frequency of flight you'd get people who know how to take their laptops out, their coats/shoes off, and the freaking keys ouf of their pockets.
Also, if you put all non-citizens in a special line (like customs, natch) you could probably get 80% of the value of profiling without having a three finger exam from the reality deniers at CAIR/ACLU/etc.