From flightaware.com
"A Delta Connection CRJ operated by Comair departing Lexington, Kentucky crashed less than a mile beyond the runway at 6:07am EDT morning. 49 people died. One person (believed to be the first officer) is in critical condition at the University of Kentucky hospital.

Blue Grass Airport (Lexington, KY) is equipped with two runways. 04/22 is 7000ft x 150ft and 08/26 is 3500ft x 75ft. Developing information says the aircraft was cleared for takeoff from runway 22 which was acknowledged only by a "roger" from the pilots. The aircaft is to believed to have taken off from runway 26, which is half the length of 22 and would have left the aircraft with insufficient room for takeoff.

FlightAware has no flight tracking information for the flight, COM191, besides the flight plan.

The aircraft tail number (not confirmed) is believed to be N431CA (aircraft registration information: N431CA)

In 1993, the pilot of an air carrier filed a report with the NASA ASRS (aviation safety reporting system) after nearly departing from runway 26 when instructed to depart from runway 22 at Lexington. The report reads: "Aircraft was cleared for immediate takeoff (traffic was inside the marker) on runway 22 at KLEX. We taxied onto the runway and told tower we needed a moment to check our departure routing with our weather radar (storms were in the area, raining at the airport). We realized our heading was not currect for our assigned runway and at that moment, tower called us to cancel the takeoff clearance because we were lined up on runway 26. We taxied clear and then held short of runway 22 for landing traffic. We took off on runway 22 and proceedd without incident. Possible contributing factors were poor visibbility and weather (rain. Confusing runway intersection and tower's request for an immediate takeoff. Suggest possible warning page (similar to Houston Hobby) to clarify multiple runway ends."

Prayers go out to the victims and their families for today's tragedy.

Although it might be too early after this tragedy (flame if you want) to give this input... Anyone still believe that it's OK to distract the flight crew with distractions from safety with hogwash such as water bottles, Starbucks Lattes and the like? I thought we'd learned long ago from the DL tragedy in DFW, and even further back with the Eastern crash in MIA that distracting crews with non-flight safety issues (whether this played a part in today's tragedy) was wrong !!!