There are people who would probably feel creepy being alone on a floor too.
I've been lucky enough to hvae the last room on the floor last night and tonight at two different places, and it's eriely quiet, I love it, nobody has gone by the room at all.
I could see how some people would be freaked out by that though, and feel safer if there are other people around.
But for noise, i would always expect the hotel to moveme if they have the space if I asked.