Mine doesn't really compare to some of the ones already posted here. However, I would say that mine occurred in F on ORD-LHR the other month. During the safety briefing, the flight attendant proceeded to give a personal safety briefing to me (1A) and 1B, since F was half-full and there was another FA doing the other aisle. He was so hilarious, especially when he told us "you don't have to take out your safety card. In first class, I do that for you. That direction is only for the people back in coach." He continued to make fun of the purser and the safety demo to 1B and me, while personalizing the safety briefing. During the gaps, he would elicit demographic information from us. It was definitely a safety briefing that I will remember.