Originally Posted by iapetus

I guess whether or not you should stay downtown depends upon how much time you'll have and what you'd like to do. Denver, Colorado, is a great town and there are lots of cool bars and restaurants downtown. So, if you're going to get there early enough on the night before your flight to take advantage of downtown, I'd suggest that. On the other hand, if you don't care much about that kind of thing, you may as well stay closer to the airport.

The one thing I can definitively say is that you don't want to stay any further west than downtown if you're flying home on a weekday. I-70 east of downtown (specifically, east of I-25) will be pretty clear and it shouldn't take you too long to get to the airport in the morning. Stay anywhere west of I-25 and dealing with traffic that morning will be a near certainty.