Definitely the train is the way to go. I have taken a taxi from the train station (about US$15,) and also walked it, when the weather is nice. With a rollerboard, I found that walking towards the Coop store and then across the bridge, walking along the river, then crossing back over once you get to a bridge past the Zum Storchen (which will be on the opposite side of the river from you,) is the easiest route. If you stay on the other side of the river, same side as the train station, along the river, there are steps to deal with and a few diversions. Of course, you can always walk down the Bahnhof Str, but it can be a bit crowded. Remember to turn left when the street trolleys, from the station, turn right.

Also, the front desk sells Inter Touch cards (12 hours of total usage was CHF35) which can be used for the wireless in the lobby area. Convenient to check your email at breakfast or at evening cocktails, as I rarely am sitting around in the room. They are good at any hotel that uses Inter Touch, but the do expire in 90 days, as I found out this past weekend at the GH Beijing, where I tried to use it on their Inter Touch system.