I can't imagine HKG-YVR being among the most profitable as one of the two daily frequencies is a 2-class A340 with no F, the other frequency is a 747 that splits premium-cabin sales with the NYC market, and a lot of CX coach tix are sold at discounts through Vancouver bucket shops to the Asian community.

I would guess HKG-SFO, HKG-NRT, perhaps HKG-SIN/BKK/TPE where they can hit businesspeople hard for short turnaround riding in the front cabins.